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The effect of retatrutide on bone density is also yet to be seen, although other GLP-1s have been shown to cause a decrease in bone density proportional to weight loss

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body comp changes at 23 months What they share Both tesamorelin and sermorelin: Are GHRH analogs that stimulate natural GH production (not synthetic HGH) Preserve your body's negative feedback loop no risk of GH overproduction Require subcutaneous injection (small insulin-type needles, virtually painless) Need a minimum 3-month commitment before aesthetic benefits appear Should be injected fasted (at least 13 hours after eating, since insulin blunts GH release) Dosing in the morning before breakfast is also an option (without eating for 30-60 minutes after dosing)